Publications

Selected Publications

Some recent publications that are representative of our approaches are the following:

• Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan A, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis AJ.  (2012)  Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages.  Cell 151:658-70.  PMCID:PMC3513387
• Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen S, Lusis AJ.  (2013)  Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.  Cell Metab. 17:49-60.  PMCID:PMC3771112
• Civelek, M., Lusis, AJ.  (2014)  Systems genetics approaches to understand complex traits. Nat. Rev. Genet. 15:34-48.  PMCID:PMC3934510
• Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ.  (2015)  Genetic architecture of insulin resistance in the mouse.  Cell Metab 21:334-46.  PMCID:PMC4349439.
• Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis AJ.  (2015)  The genetic architecture of NAFLD among inbred strains of mice.  Elife 4:e05607.  PMCID:PMC4493743
• Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ.  (2015)  Genetic and environmental control of host-gut microbiota interactions.  Genome Res. 25:1558-69.  PMCID:PMC4579341
• Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis AJ.  (2017)  Systems genetics approach identifies gene pathways and Adamts2 as drivers of isoproterenol-induced cardiac hypertrophy and cardiomyopathy in mice.  Cell Syst. 4:121-128.  PMCID:PMC5338604.
• Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stančáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, Boehnke M, Laakso M, Mohlke KL, Lusis AJ.  (2017)  Genetic regulation of adipose gene expression and cardio-metabolic traits.  Am J Hum Genet. 100:428-443.  PMCID:PMC5339333.
• Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ.  (2018)  A strategy for discovery of endocrine interactions with application to whole-body metabolism.  Cell Metab. 27:1138-1155. PMCID:PMC5935137.
• Hui ST, Kurt Z, Tuominen I, Norheim F, Davis RC, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ.  (2018)  The genetic architecture of diet-induced hepatic fibrosis in mice.  Hepatology 68:2182-2196.  PMCID:PMC6269199
• Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ.  (2019)  Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits.  Cell Metab. 29:932-949.  PMCID:PMC6447452
• Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ.  (2021)  Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.  Nat Metab. 3:1552-1568.  PMCID:PMC8909918
• Björkegren JLM, Lusis AJ.  (2022)  Atherosclerosis: Recent developments. Cell 185:1630-1645.  PMCID:PMC9119695.
• Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ.  (2022)  Sex differences in heart mitochondria regulate diastolic dysfunction. Nat Commun. 13:3850.  PMCID:PMC9253085.
• Cao Y, Wang Y, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, Lusis AJ.  (2022)  Liver-heart crosstalk mediated by coagulation factor XI (F11) protects against heart failure.  Science 377:1399-1406.  PMCID:PMC9639660
• Wang YC, Cao Y, Pan C, Zhou Z, Yang L, Lusis AJ.  (2023)  Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet. J Exp Med. 220:e20221437. PMCID:PMC10038833
• Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ.  (2024)  Indole-3-propionic acid protects against heart failure with preserved ejection fraction. Circ Res. 2024 134:371-389. PMCID:PMC10923103.